PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases.

doi:10.1080/08916934.2021.1946796

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Article

PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases.

Autoimmunity - 1 Nov 2021

Kawabata Mayumi, Inoue Naoya, Watanabe Mikio, Kobayashi Ayaka, Hidaka Yoh, Miyauchi Akira, Iwatani Yoshinori

Abstract excerpt

The programmed cell death-1 (PD-1)/PD ligand pathway plays a key role in the maintenance of peripheral tolerance by enhancing the suppressive activity of regulatory T (Treg) cells. The promoter activity of the A allele of PD1 rs36084323 G/A polymorphism is lower than that of the G allele. We examined the association of PD1 gene polymorphisms, PD-1 expression on Treg cells, and thyroid PD-1/PD-1 ligand (PD-L1)...

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PMID: 34494503
DOI: 10.1080/08916934.2021.1946796

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