Article
Genetic and immunologic features of recurrent stage I lung adenocarcinoma.
Scientific reports - 8 Dec 2021
Kratz Johannes R, Li Jack Z, Tsui Jessica, Lee Jen C, Ding Vivianne W, Rao Arjun A, Mann Michael J, Chan Vincent, Combes Alexis J, Krummel Matthew F, Jablons David M
Abstract excerpt
Although surgery for early-stage lung cancer offers the best chance of cure, recurrence still occurs between 30 and 50% of the time. Why patients frequently recur after complete resection of early-stage lung cancer remains unclear. Using a large cohort of stage I lung adenocarcinoma patients, distinct genetic, genomic, epigenetic, and immunologic profiles of recurrent tumors were analyzed using a novel recurrence...
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