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Article

Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro.

Molecular pharmacology - 1 Dec 2021

Mosher Eric P, Eberhard Colten D, Bumpus Namandjé N

Abstract excerpt

Tenofovir (TFV) is a key component of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP). TFV is a nucleotide analog reverse-transcriptase inhibitor prodrug that requires two separate phosphorylation reactions by intracellular kinases to form the active metabolite tenofovir-diphosphate (TFV-DP). Muscle-type creatine kinase (CKM) has previously been demonstrated to be the kinase most responsible...

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Identifiers

PMID: 34561299
DOI: 10.1124/molpharm.121.000348
PMCID: PMC8626780

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