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Article

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.

EBioMedicine - 1 Sept 2015

Lade Julie M, To Elaine E, Hendrix Craig W, Bumpus Namandjé N

Abstract excerpt

Tenofovir (TFV) is used in combination with other antiretroviral drugs for human immunodeficiency virus (HIV) treatment and prevention. TFV requires two phosphorylation steps to become pharmacologically active; however, the kinases that activate TFV in cells and tissues susceptible to HIV infection have yet to be identified. Peripheral blood mononuclear cells (PBMC), vaginal, and colorectal tissues were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26501112
DOI: 10.1016/j.ebiom.2015.07.008
PMCID: PMC4588390

Genes

CKM
PKLR
PKM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.PMID 26501112Read ↗

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