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Article

Role of miR‐200c in Myogenic Differentiation Impairment via p66Shc: Implication in Skeletal Muscle Regeneration of Dystrophic mdx Mice

1 Jan 2018

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a genetic disease associated with mutations of Dystrophin gene that regulate myofiber integrity and muscle degeneration, characterized by oxidative stress increase. We previously published that reactive oxygen species (ROS) induce miR‐200c that is responsible for apoptosis and senescence. Moreover, we demonstrated that miR‐200c increases ROS production and phosphorylates...

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PMID: 29636844
DOI: 10.1155/2018/4814696

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