Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts

27 Oct 2021

Abstract excerpt

BACKGROUND: The absence of dystrophin has gave a massive impact on myotube development in Muscular Dystrophy pathogenesis. One of the conserved signaling pathways involved in skeletal muscle differentiation is the PI3K/Akt/mTOR pathway that plays a vital role in autophagy regulation. To further understand and establish targeted therapy in dystrophin-deficient myoblasts, protein expression profiling has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Exercise and Physiological Responses
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34706731
DOI: 10.1186/s12964-021-00785-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblastsPMID 34706731Read ↗

Perturbation of PI3K/Akt Signaling affected Autophagy Modulation in Dystrophin-Deficient MyoblastsSemantic proximity Read ↗

Perturbation of PI3K/Akt Signaling Affected Autophagy Modulation in Dystrophin-deficient MyoblastsSemantic proximity Read ↗

Altered signal transduction pathways and induction of autophagy in human myotonic dystrophy type 1 myoblastsSemantic proximity Read ↗

Skeletal Muscle Homeostasis in Duchenne Muscular Dystrophy: Modulating Autophagy as a Promising Therapeutic StrategySemantic proximity Read ↗

Autophagy as a new therapeutic target in Duchenne muscular dystrophySemantic proximity Read ↗

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblastsSemantic proximity Read ↗

“Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular DisordersSemantic proximity Read ↗

Autophagic dysfunction and autophagosome escape in the mdx <i>mus musculus</i> model of Duchenne muscular dystrophySemantic proximity Read ↗

Autophagy regulates satellite cell ability to regenerate normal and dystrophic musclesSemantic proximity Read ↗

PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways.Semantic proximity Read ↗

Coordinated Metabolic Changes and Modulation of Autophagy during MyogenesisSemantic proximity Read ↗

Myogenic Akt signaling upregulates the utrophin–glycoprotein complex and promotes sarcolemma stability in muscular dystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.