Article
CXCR4 involvement in neurodegenerative diseases.
Translational psychiatry - 11 Apr 2018
Bonham Luke W, Karch Celeste M, Fan Chun C, Tan Chin, Geier Ethan G, Wang Yunpeng, Wen Natalie, Broce Iris J, Li Yi, Barkovich Matthew J, Ferrari Raffaele, Hardy John, Momeni Parastoo, Höglinger Günter, Müller Ulrich, Hess Christopher P, Sugrue Leo P, Dillon William P, Schellenberg Gerard D, Miller Bruce L, Andreassen Ole A, Dale Anders M, Barkovich A James, Yokoyama Jennifer S, Desikan Rahul S
Abstract excerpt
Neurodegenerative diseases likely share common underlying pathobiology. Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic risk across several neurodegenerative diseases. Using genome-wide association data from large studies (total n = 82,337 cases and controls), we utilized a previously validated approach to...
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