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Article

Characterization of IDH1 p.R132H Mutant Clones Using Mutation-specific Antibody in Myeloid Neoplasms.

The American journal of surgical pathology - 1 May 2018

Kurt Habibe, Bueso-Ramos Carlos E, Khoury Joseph D, Routbort Mark J, Kanagal-Shamanna Rashmi, Patel Umang V, Jorgensen Jeffrey L, Wang Sa A, Ravandi Farhad, DiNardo Courtney, Luthra Rajyalakshmi, Medeiros L Jeffrey, Patel Keyur P

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations occur in a variety of myeloid neoplasms. Immunohistochemistry (IHC)-based direct visualization of mutant clones of hematopoietic cells can be useful for rapid diagnostic screening and for monitoring treatment response. In this study, we first evaluated the sensitivity and specificity of the IDH1 p.R132H mutation-specific antibody by IHC. All IDH1 wild type...

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Share to Antibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Myeloid Cells

Share to Myeloproliferative Disorders

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Source

Identifiers

PMID: 29635257
DOI: 10.1097/PAS.0000000000000970

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Research trail→

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Characterization of IDH1 p.R132H Mutant Clones Using Mutation-specific Antibody in Myeloid Neoplasms.PMID 29635257Read ↗

Monoclonal antibody specific for IDH1 R132H mutation.Semantic proximity Read ↗

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