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Article

IDH1- and IDH2-mutated myeloid neoplasms: mutational pattern, clonal hierarchy, and the role in AML transformation.

Blood advances - 26 May 2026

Huber Sandra, Goessweiner Flora, Walter Wencke, Summerer Isolde, Meggendorfer Manja, Ordemann Rainer, Pohlkamp Christian, Kneisel Niclas, Haferlach Claudia, Kern Wolfgang, Haferlach Torsten, Delic Sabit, Hoermann Gregor

Abstract excerpt

ABSTRACT: Mutations in the isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, are recurrently found in patients with myeloid neoplasms (MN) and clinically targeted by small-molecule inhibitors. We aimed to comprehensively study the genetic pattern and underlying clonal architecture in a large cohort of 12 071 patients (acute myeloid leukemia [AML], n = 4113; myelodysplastic neoplasms [MDS], n = 6316; or chronic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41860384
DOI: 10.1182/bloodadvances.2025019387
PMCID: PMC13196520

Genes

IDH1
IDH2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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