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Article

Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

The Journal of molecular diagnostics : JMD - 1 Nov 2015

Platt Mia Y, Fathi Amir T, Borger Darrell R, Brunner Andrew M, Hasserjian Robert P, Balaj Leonora, Lum Amy, Yip Stephen, Dias-Santagata Dora, Zheng Zongli, Le Long P, Graubert Timothy A, Iafrate A John, Nardi Valentina

Abstract excerpt

Studies in myeloid neoplasms have described recurrent IDH1 and IDH2 mutations as primarily mutually exclusive. Over a 6-month period of clinical testing with a targeted next-generation sequencing assay, we evaluated 92 patients with acute myeloid leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia and identified a subset of 21 patients (23%) who harbored mutations in either IDH1 or IDH2. Of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26331834
DOI: 10.1016/j.jmoldx.2015.06.004
PMCID: PMC4630164

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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