Article
Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study.
Leukemia - 1 May 2010
Ho P A, Alonzo T A, Kopecky K J, Miller K L, Kuhn J, Zeng R, Gerbing R B, Raimondi S C, Hirsch B A, Oehler V, Hurwitz C A, Franklin J L, Gamis A S, Petersdorf S H, Anderson J E, Reaman G H, Baker L H, Willman C L, Bernstein I D, Radich J P, Appelbaum F R, Stirewalt D L, Meshinchi S
Abstract excerpt
Recent whole-genome sequencing efforts led to the identification of IDH1(R132) mutations in acute myeloid leukemia (AML) patients. We studied the prevalence and clinical implications of IDH1 genomic alterations in pediatric and adult AML. Diagnostic DNA from 531 AML patients treated on Children's Oncology Group trial COG-AAML03P1 (N=257), and Southwest Oncology Group trials SWOG-9031, SWOG-9333 and SWOG-9500...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.