Article
Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment.
Cardiovascular drugs and therapy - 1 Apr 2015
Cui Hanbin, Lin Shaoyi, Chen Xiaomin, Gao Wenhui, Li Xiaojing, Zhou Honglin, Du Weiping, Wang Shenghuang, Zhao Ruochi
Abstract excerpt
PURPOSE: Patients with high on-treatment platelet reactivity (HPR) against aspirin or clopidogrel are at increased risk for adverse cardiovascular events. In this study, we explored the predictive value of common SNPs for the on-treatment platelet reactivity (OPR) against aspirin and clopidogrel assessed by VerifyNow assays. METHODS: This study recruited 286 Han Chinese individuals undergoing antiplatelet...
Topics
- Aged
- Asian People
- Aspirin
- Clopidogrel
- Cytochrome P-450 CYP2C19
- Drug Therapy, Combination
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Platelet Aggregation
- Platelet Aggregation Inhibitors
- Polymorphism, Single Nucleotide