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Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Clinical pharmacology and therapeutics - 1 Dec 2018

Gazzaz Malaz, Kinzig Martina, Schaeffeler Elke, Jübner Martin, Hsin Chih-Hsuan, Li Xia, Taubert Max, Trueck Christina, Iltgen-Breburda Juliane, Kraus Daria, Queckenberg Christian, Stoffel Marc, Schwab Matthias, Sörgel Fritz, Fuhr Uwe

Abstract excerpt

We quantified the effect of acute ethanol exposure (initial blood concentrations 0.7 g/L) on major drug metabolizing enzymes and p-glycoprotein. Sixteen healthy Caucasians participated in a randomized crossover study with repeated administration of either vodka or water. Enzyme/transporter activity was assessed by a cocktail of probe substrates, including caffeine (CYP1A2/NAT2), tolbutamide (CYP2C9), omeprazole...

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PMID: 29633238
DOI: 10.1002/cpt.1083

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NAT2

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