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Article

Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations.

Scientific reports - 24 Aug 2018

Bedada Worku, de Andrés Fernando, Engidawork Ephrem, Hussein Jemal, LLerena Adrián, Aklillu Eleni

Abstract excerpt

In a one-way cross-over study, we investigated the effect of Khat, a natural amphetamine-like psychostimulant plant, on catalytic activities of five major drug-metabolizing cytochrome P450 (CYP) enzymes. After a one-week Khat abstinence, 63 Ethiopian male volunteers were phenotyped using cocktail probe drugs (caffeine, losartan, dextromethorphan, omeprazole). Phenotyping was repeated after a one-week daily use of...

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Identifiers

PMID: 30143732
DOI: 10.1038/s41598-018-31191-1
PMCID: PMC6109098

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