Article
Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.
PLoS biology - 1 Apr 2018
Robinson Susan W, Bourgognon Julie-Myrtille, Spiers Jereme G, Breda Carlo, Campesan Susanna, Butcher Adrian, Mallucci Giovanna R, Dinsdale David, Morone Nobuhiro, Mistry Raj, Smith Tim M, Guerra-Martin Maria, Challiss R A John, Giorgini Flaviano, Steinert Joern R
Abstract excerpt
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantly, cross signaling between S-nitrosylation and prenylation can have major regulatory potential. However, the exact protein targets and resulting changes in function...
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