Article
Mutation of N-linked glycosylation in EpCAM affected cell adhesion in breast cancer cells.
Biological chemistry - 26 Sept 2017
Liu Xue, Gao Jiujiao, Sun Yan, Zhang Dandan, Liu Tingjiao, Yan Qiu, Yang Xuesong
Abstract excerpt
Epithelial cell adhesion molecule (EpCAM) expression is elevated in breast cancer tissue, and correlates with the cancer metastasis and cell adhesion. Although EpCAM glycosylation is supposed to be associated with its function, the contribution of N-glycosylation to its function remains unclear. Here we analyzed cell adhesion ability of EpCAM in breast cancer cells. The results showed that EpCAM expression was...
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