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The Intracellular and Secreted Sides of Osteopontin and Their Putative Physiopathological Roles

2 Feb 2023

Abstract excerpt

Classically, osteopontin (OPN) has been described as a secreted glycophosprotein. Indeed, most data concerning its physiological and pathological roles are mainly related to the secreted OPN (sOPN). However, there are several instances in which intracellular OPN (iOPN) has been described, presenting some specific roles in distinct experimental models, such as in the immune system, cancer cells, and neurological...

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PMID: 36769264
DOI: 10.3390/ijms24032942

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