Article

The half-life of the bone-derived hormone osteocalcin is regulated through <i>O</i> -glycosylation in mice, but not in humans

2020-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity. Here, we uncover O -glycosylation as a novel PTM present on mouse OCN and occurring on a single serine (S8) independently of its carboxylation and endoproteolysis, two other PTMs regulatin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 491bc359-6435-509a-bc91-3bfead03d832
DOI: 10.1101/2020.07.16.206656

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The half-life of the bone-derived hormone osteocalcin is regulated through <i>O</i> -glycosylation in mice, but not in humansDOI 10.1101/2020.07.16.206656Read

Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surfaceSemantic proximity Read

The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?Semantic proximity Read

The restricted nature of protein glycosylation in the mammalian brainSemantic proximity Read

Role of Glycosyltransferase 25 Domain 1 in Type I Collagen Glycosylation and Molecular Phenotypes.Semantic proximity Read

Sulfation of Glycosaminoglycans and Its Implications in Human Health and Disorders.Semantic proximity Read

Osteopontin: Its Properties, Recent Studies, and Potential ApplicationsSemantic proximity Read

The Intracellular and Secreted Sides of Osteopontin and Their Putative Physiopathological RolesSemantic proximity Read

Mucin-type <i>O</i> -glycans regulate proteoglycan stability and chondrocyte maturationSemantic proximity Read

Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein Klotho.Semantic proximity Read

The immune duality of osteopontin and its therapeutic implications for kidney transplantationSemantic proximity Read

O-Fucosylation of CCN1 is required for its secretion.Semantic proximity Read

Rationale for the Development of Recombinant Human CC10 as a Therapeutic for Inflammatory and Fibrotic DiseaseSemantic proximity Read