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Article

A functional motif QLYxxYP is essential for osteopontin induced T lymphocyte activation and migration.

Biochemical and biophysical research communications - 13 Mar 2009

Dai Jianxin, Cao Zhiguo, Kang Yanshen, Fan Kexing, Ji Guanghui, Yang Haiou, Wang Huajing, Gao Jie, Wang Hao, Guo Yajun

Abstract excerpt

Osteopontin (OPN) plays an important role in regulating lymphocyte adhesion and cytokine production associated with inflammatory processes and autoimmune diseases. Here we developed and characterized a monoclonal antibody F8E11 specific for human OPN (hOPN). F8E11 could inhibit OPN-induced lymphocyte activation and migration. Epitope mapping showed that F8E11 could specifically recognize the peptide QLYxxYP. In...

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Source

Identifiers

PMID: 19285028
DOI: 10.1016/j.bbrc.2009.01.157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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