Article
Effect of the African-specific promoter polymorphisms on the SLC22A2 gene expression levels.
Drug metabolism and personalized therapy - 27 Jun 2018
Pearce Brendon, Abrahams-October Zainonesa, Xhakaza Lettilia, Jacobs Clifford, Benjeddou Mongi
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms in promoter regions have been shown to alter the transcription of genes. Thus, SNPs in SLC22A2 can result in inter-individual variable response to medication. METHODS: The objective of the study was to investigate the effect of the African-specific promoter polymorphisms on the SLC22A2 gene expression levels in vitro. These included rs572296424 and rs150063153, which...
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