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Article

Serotonin transporter promoter polymorphism in African Americans : allele frequencies and implications for treatment.

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2003

Lotrich Francis E, Pollock Bruce G, Ferrell Robert E

Abstract excerpt

BACKGROUND: Americans of African ancestry are less likely to receive a selective serotonin reuptake inhibitor (SSRI) for treatment of major depressive disorder than Americans of European ancestry. A functional insertion/deletion polymorphism in the promoter of the serotonin transporter (5-HTT) gene SLC6A4 has been shown to modulate SLC6A4 transcription, affecting response to SSRIs. Several studies in populations...

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Identifiers

PMID: 12749731
DOI: 10.2165/00129785-200303020-00007

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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