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Article

Effects of iron on the aggregation propensity of the N-terminal fibrillogenic polypeptide of human apolipoprotein A-I.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Aug 2018

Del Giudice Rita, Pesce Alessandra, Cozzolino Flora, Monti Maria, Relini Annalisa, Piccoli Renata, Arciello Angela, Monti Daria Maria

Abstract excerpt

Specific mutations in APOA1 gene lead to systemic, hereditary amyloidoses. In ApoA-I related amyloidosis involving the heart, amyloid deposits are mainly constituted by the 93-residue N-terminal region of the protein, here indicated as [1-93]ApoA-I. Oxidative stress is known to be an enhancing factor for protein aggregation. In healthy conditions, humans are able to counteract the formation and the effects of...

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Share to Amyloidosis, Familial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29623474
DOI: 10.1007/s10534-018-0101-y

Genes

APOA1

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