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Metals in alzheimer's disease: a systemic perspective

26 Oct 2011

Abstract excerpt

Many results from in vitro and animal studies have highlighted the important role played by specific metals, such as copper, iron and zinc, in the diverse toxic pathways on which Alzheimer's disease (AD) develops. Metals seem to mediate the aggregation and neurotoxicity of amyloid-beta (ABeta), the main constituent of the amyloid plaques, commonly seen in AD (1). The link between metals and AD has been mostly...

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PMID: 22201755
DOI: 10.2741/3938

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