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Article

Tetracycline inhibits W7FW14F apomyoglobin fibril extension and keeps the amyloid protein in a pre-fibrillar, highly cytotoxic state.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2006

Malmo Clorinda, Vilasi Silvia, Iannuzzi Clara, Tacchi Silvia, Cametti Cesare, Irace Gaetano, Sirangelo Ivana

Abstract excerpt

A significant number of fatal diseases are classified as protein deposition disorders, in which a normally soluble protein is deposited in an insoluble amyloid form. It has been reported that tetracycline exhibits anti-amyloidogenic activity by inhibiting aggregate formation and disaggregating preformed fibrils. In this work, we examined the effect induced by the presence of tetracycline on the fibrillogenesis...

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Identifiers

PMID: 16317065
DOI: 10.1096/fj.05-4652fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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