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Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer.

Experimental & molecular medicine - 6 Apr 2018

Choi Ji-Hye, Kim Young-Bae, Ahn Ji Mi, Kim Min Jae, Bae Won Jung, Han Sang-Uk, Woo Hyun Goo, Lee Dakeun

Abstract excerpt

Diffuse-type gastric cancer (DGC) is a GC subtype with heterogeneous clinical outcomes. Lymph node metastasis of DGC heralds a dismal progression, which hampers the curative treatment of patients. However, the genomic heterogeneity of DGC remains unknown. To identify genomic variations associated with lymph node metastasis in DGC, we performed whole exome sequencing on 23 cases of DGC and paired non-tumor tissues...

Topics

Adult
Aged
DNA Copy Number Variations
Female
Genetic Variation
Genomics
Humans
Lymph Nodes
Lymphatic Metastasis
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Staging

Stomach Neoplasms

Exome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29622765
DOI: 10.1038/s12276-017-0009-6
PMCID: PMC5938030

Genes

CMTM2
CDH1
RHOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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