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Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes

5 Apr 2018

Abstract excerpt

Oxidative stress (OS)-induced retinal pigment epithelium (RPE) cell apoptosis is critically implicated in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Heterochromatin, a compact and transcriptional inert chromatin structure, has been recently shown to be dynamically regulated in response to stress stimuli. The functional mechanism of heterochromatin on...

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PMID: 29622681
DOI: 10.1073/pnas.1715237115

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