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Article

Molecular dissection of formation of senescence-associated heterochromatin foci.

Molecular and cellular biology - 1 Mar 2007

Zhang Rugang, Chen Wei, Adams Peter D

Abstract excerpt

Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF), are thought to contribute to the irreversible cell cycle exit in many senescent cells by repressing the expression of proliferation-promoting genes such as cyclin A. SAHF contain known heterochromatin-forming proteins, such as...

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Identifiers

PMID: 17242207
DOI: 10.1128/MCB.02019-06
PMCID: PMC1820509

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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