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Article

IL-23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice.

Journal of the American Heart Association - 4 Apr 2018

Engelbertsen Daniel, Depuydt Marie A C, Verwilligen Robin A F, Rattik Sara, Levinsohn Erik, Edsfeldt Andreas, Kuperwaser Felicia, Jarolim Petr, Lichtman Andrew H

Abstract excerpt

BACKGROUND: Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. METHODS AND RESULTS: We used heterozygous...

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Share to Aorta, Thoracic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin

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Source

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Identifiers

PMID: 29618473
DOI: 10.1161/JAHA.117.008257
PMCID: PMC6015431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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