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Article

Tc17 CD8+ T cells accumulate in murine atherosclerotic lesions, but do not contribute to early atherosclerosis development.

Cardiovascular research - 17 Dec 2021

van Duijn Janine, de Jong Maaike J M, Benne Naomi, Leboux Romain J T, van Ooijen Marieke E, Kruit Nicky, Foks Amanda C, Jiskoot Wim, Bot Ilze, Kuiper Johan, Slütter Bram

Abstract excerpt

AIMS: CD8+ T cells can differentiate into subpopulations that are characterized by a specific cytokine profile, such as the Tc17 population that produces interleukin-17. The role of this CD8+ T-cell subset in atherosclerosis remains elusive. In this study, we therefore investigated the contribution of Tc17 cells to the development of atherosclerosis. METHODS AND RESULTS: Flow cytometry analysis of atherosclerotic...

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Identifiers

PMID: 33063097
DOI: 10.1093/cvr/cvaa286
PMCID: PMC8683708

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