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Article

Two Groups of Cocirculating, Epidemic Clostridiodes difficile Strains Microdiversify through Different Mechanisms.

Genome biology and evolution - 1 Mar 2018

Murillo Tatiana, Ramírez-Vargas Gabriel, Riedel Thomas, Overmann Jörg, Andersen Joakim M, Guzmán-Verri Caterina, Chaves-Olarte Esteban, Rodríguez César

Abstract excerpt

Clostridiodes difficile strains from the NAPCR1/ST54 and NAP1/ST01 types have caused outbreaks despite of their notable differences in genome diversity. By comparing whole genome sequences of 32 NAPCR1/ST54 isolates and 17 NAP1/ST01 recovered from patients infected with C. difficile we assessed whether mutation, homologous recombination (r) or nonhomologous recombination (NHR) through lateral gene transfer (LGT)...

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Identifiers

PMID: 29617810
DOI: 10.1093/gbe/evy059
PMCID: PMC5888409

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