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Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico.

Microbial genomics - 1 May 2020

Guerrero-Araya Enzo, Meneses Claudio, Castro-Nallar Eduardo, Guzmán D Ana M, Álvarez-Lobos Manuel, Quesada-Gómez Carlos, Paredes-Sabja Daniel, Rodríguez César

Abstract excerpt

Clostridium difficile B1/NAP1/RT027/ST01 has been responsible for outbreaks of antibiotic-associated diarrhoea in clinical settings worldwide and is associated with severe disease presentations and increased mortality rates. Two fluoroquinolone-resistant (FQR) lineages of the epidemic B1/NAP1/RT027/ST01 strain emerged in the USA in the early 1990s and disseminated trans continentally (FQR1 and FQR2). However, it...

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PMID: 32176604
DOI: 10.1099/mgen.0.000355
PMCID: PMC7371124

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