Article
Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.
Journal of clinical microbiology - 1 Mar 2017
Cairns M D, Preston M D, Hall C L, Gerding D N, Hawkey P M, Kato H, Kim H, Kuijper E J, Lawley T D, Pituch H, Reid S, Kullin B, Riley T V, Solomon K, Tsai P J, Weese J S, Stabler R A, Wren B W
Abstract excerpt
The diarrheal pathogen Clostridium difficile consists of at least six distinct evolutionary lineages. The RT017 lineage is anomalous, as strains only express toxin B, compared to strains from other lineages that produce toxins A and B and, occasionally, binary toxin. Historically, RT017 initially was reported in Asia but now has been reported worldwide. We used whole-genome sequencing and phylogenetic analysis to...
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