Article
Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Nature genetics - 1 Jan 2013
He Miao, Miyajima Fabio, Roberts Paul, Ellison Louise, Pickard Derek J, Martin Melissa J, Connor Thomas R, Harris Simon R, Fairley Derek, Bamford Kathleen B, D'Arc Stephanie, Brazier Jon, Brown Derek, Coia John E, Douce Gill, Gerding Dale, Kim Hee Jung, Koh Tse Hsien, Kato Haru, Senoh Mitsutoshi, Louie Tom, Michell Stephen, Butt Emma, Peacock Sharon J, Brown Nick M, Riley Tom, Songer Glen, Wilcox Mark, Pirmohamed Munir, Kuijper Ed, Hawkey Peter, Wren Brendan W, Dougan Gordon, Parkhill Julian, Lawley Trevor D
Abstract excerpt
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global spread remain unknown. Here, we define the global population structure of C. difficile 027/BI/NAP1 using whole-genome sequencing and phylogenetic analysis. We show...
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