Article
Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease.
PloS one - 1 Jan 2013
Eyre David W, Walker A Sarah, Freeman Jane, Baines Simon D, Fawley Warren N, Chilton Caroline H, Griffiths David, Vaughan Alison, Crook Derrick W, Peto Tim E A, Wilcox Mark H
Abstract excerpt
BACKGROUND: Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates and individuals. METHODS: Serial isolates from two scenarios were whole genome sequenced. Firstly, 62 isolates from 29 timepoints from three in vitro gut models, inoculated with a...
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