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Article

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.

Nature communications - 3 Apr 2018

Liu Chao, Han Tianxu, Stachura David L, Wang Huawei, Vaisman Boris L, Kim Jungsu, Klemke Richard L, Remaley Alan T, Rana Tariq M, Traver David, Miller Yury I

Abstract excerpt

Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance. Knockout of Lpl or its obligatory cofactor Apoc2 results in significantly reduced HSPC expansion during definitive hematopoiesis in zebrafish. A human APOC2 mimetic peptide or the human very...

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Source

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Identifiers

PMID: 29615667
DOI: 10.1038/s41467-018-03775-y
PMCID: PMC5882990

Genes

LPL
APOC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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