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Article

A dnaC mutation in Escherichia coli that affects copy number of ColE1-like plasmids and the PriA-PriB (but not Rep-PriC) pathway of chromosomal replication restart.

Genetics - 1 Mar 2004

Harinarayanan R, Gowrishankar J

Abstract excerpt

Escherichia coli nusG and rho mutants, which are defective in transcription termination, are killed following transformation with several ColE1-like plasmids that lack the plasmid-encoded copy-number regulator gene rom because of uncontrolled plasmid replication within the cells. In this study, a mutation [dnaC1331(A84T)] in the dnaC gene encoding the replicative helicase-loading protein was characterized as a...

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Identifiers

PMID: 15082538
DOI: 10.1534/genetics.166.3.1165
PMCID: PMC1470795

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