Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells.

PloS one - 1 Jan 2013

Ashmole Ian, Duffy S Mark, Leyland Mark L, Bradding Peter

Abstract excerpt

BACKGROUND: The influx of extracellular Ca(2+) into mast cells is critical for the FcεR1-dependent release of preformed granule-derived mediators and newly synthesised autacoids and cytokines. The Orai(CRACM) ion channel family provide the major pathway through which this Ca(2+) influx occurs. Ho...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to beta-N-Acetylhexosaminidases
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to ORAI1 Protein

Share to Patch-Clamp Techniques

Share to Receptors, IgE

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 24040356
DOI: 10.1371/journal.pone.0074895
PMCID: PMC3769304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24040356-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells.PMID 24040356Read ↗

Study of Endogenous CRAC Channels in Human Mast Cells Using an Adenoviral Delivery System to Transduce Cells with Orai-Targeting shRNAs or with cDNAs Expressing Dominant-Negative Orai Channel Mutations.Semantic proximity Read ↗

Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.Semantic proximity Read ↗

CRAC channels and patho-physiology of peripheral organ systems.Semantic proximity Read ↗

Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.Semantic proximity Read ↗

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activationSemantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and TranscriptionSemantic proximity Read ↗

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation.Semantic proximity Read ↗

Hair loss and defective T- and B-cell function in mice lacking ORAI1.Semantic proximity Read ↗

Ion channel gene expression in human lung, skin, and cord blood-derived mast cells.Semantic proximity Read ↗

Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell FunctionSemantic proximity Read ↗

TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell DeathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.