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Article

Recurrently Mutated Genes Differ between Leptomeningeal and Solid Lung Cancer Brain Metastases.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2018

Li Yingmei, Liu Boxiang, Connolly Ian David, Kakusa Bina Wasunga, Pan Wenying, Nagpal Seema, Montgomery Stephen B, Hayden Gephart Melanie

Abstract excerpt

When compared with solid brain metastases from NSCLC, leptomeningeal disease (LMD) has unique growth patterns and is rapidly fatal. Patients with LMD do not undergo surgical resection, limiting the tissue available for scientific research. In this study we performed whole exome sequencing on eight samples of LMD to identify somatic mutations and compared the results with those for 26 solid brain metastases. We...

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Identifiers

PMID: 29604399
DOI: 10.1016/j.jtho.2018.03.018
PMCID: PMC8407522

Genes

EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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