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Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastases from lung adenocarcinomas.

Cancer letters - 28 Nov 2024

Zhao Yang, Zhang Dainan, Meng Bo, Zhang Yong, Ma Shunchang, Zeng Jiaming, Wang Xi, Peng Tao, Gong Xiaoyun, Zhai Rui, Dong Lianhua, Jiang You, Dai Xinhua, Fang Xiang, Jia Wang

Abstract excerpt

Brain metastasis is a major cause of poor prognosis and death in lung adenocarcinoma (LUAD); however, the understanding of therapeutic strategies and mechanisms for brain metastases from LUAD (BM-LUAD) remains notably limited, especially at the proteomics levels. To address this issue, we conducted integrated proteomic and glycoproteomic analyses on 49 BM-LUAD tumors, revealing two distinct subtypes of the...

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PMID: 39341452
DOI: 10.1016/j.canlet.2024.217262

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