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Article

Cell-Cycle and DNA-Damage Response Pathway Is Involved in Leptomeningeal Metastasis of Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2018

Fan Yun, Zhu Xuehua, Xu Yan, Lu Xuesong, Xu Yanjun, Wang Mengzhao, Xu Haiyan, Ding Jingyan, Ye Xin, Fang Luo, Huang Zhiyu, Gong Lei, Lu Hongyang, Mao Weimin, Hu Min

Abstract excerpt

Purpose: Leptomeningeal metastasis (LM) is a detrimental complication of non-small cell lung cancer (NSCLC) and associated with poor prognosis. However, the underlying mechanisms of the metastasis process are still poorly understood.Experimental Design: We performed next-generation panel sequencing of primary tumor tissue, cerebrospinal fluid (CSF), and matched normal controls from epidermal growth factor...

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Source

Identifiers

PMID: 29030356
DOI: 10.1158/1078-0432.CCR-17-1582

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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