Article
Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2009
Toyoda Yu, Sakurai Aki, Mitani Yasumasa, Nakashima Masahiro, Yoshiura Koh-ichiro, Nakagawa Hiroshi, Sakai Yasuo, Ota Ikuko, Lezhava Alexander, Hayashizaki Yoshihide, Niikawa Norio, Ishikawa Toshihisa
Abstract excerpt
One single-nucleotide polymorphism (SNP), 538G>A (Gly180Arg), in the ABCC11 gene determines the type of earwax. The G/G and G/A genotypes correspond to the wet type of earwax, whereas A/A corresponds to the dry type. Wide ethnic differences exist in the frequencies of those alleles, reflecting global migratory waves of the ancestors of humankind. We herein provide the evidence that this genetic polymorphism has...
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