Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults.

doi:10.1128/spectrum.01698-24

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Article

Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults.

Microbiology spectrum - 4 Feb 2025

Amari Yasunobu, Hosonuma Masahiro, Mizukami Takuya, Isobe Junya, Azetsu Yuki, Funayama Eiji, Maruyama Yuki, Tsurui Toshiaki, Tajima Kohei, Sasaki Aya, Yamazaki Yoshitaka, Nakano Ryota, Sano Yutaka, Ishida Atsushi, Nakanishi Tatsuya, Mochizuki Seiji, Yoshizawa Yuri, Kumagai Sumito, Yasuhara Sakiko, Ryu Kakei, Oguchi Tatsunori, Kuramasu Atsuo, Yoshimura Kiyoshi, Sambe Takehiko, Kobayashi Sei, Uchida Naoki

Abstract excerpt

The concept of genome-microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates the local microbiota, is important in the pathogenesis of human disease. In otolaryngology, the resident bacterial microbiota is reportedly altered in non-infectious ear diseases, such as otitis media pearls and exudative otitis media. We hypothesized that a single-nucleotide...

Read the complete abstract on PubMed

Topics

Humans
Ear Canal
ATP-Binding Cassette Transporters
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Polymorphism, Single Nucleotide

Microbiota

Cerumen

Middle Aged

Bacteria

Corynebacterium

Healthy Volunteers

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 39817749
DOI: 10.1128/spectrum.01698-24
PMCID: PMC11792512

Genes

ABCC11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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