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Article

Adaptive mutations promote hepatitis C virus assembly by accelerating core translocation to the endoplasmic reticulum.

The Journal of biological chemistry - 1 Jan 2000

Zheng Fuxiang, Li Ni, Xu Yi, Zhou Yuanping, Li Yi-Ping

Abstract excerpt

The envelopment of hepatitis C virus (HCV) is believed to occur primarily in the endoplasmic reticulum (ER)-associated membrane, and the translocation of viral Core protein from lipid droplets (LDs) to the ER is essential for the envelopment of viral particles. However, the factors involved are not completely understood. Herein, we identified eight adaptive mutations that enhanced virus spread and infectivity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33144326
DOI: 10.1074/jbc.RA120.016010
PMCID: PMC7949066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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