Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

The Journal of cell biology - 7 May 2018

Carroll Thomas D, Newton Ian P, Chen Yu, Blow J Julian, Näthke Inke

Abstract excerpt

During late mitosis and the early G1 phase, the origins of replication are licensed by binding to double hexamers of MCM2-7. In this study, we investigated how licensing and proliferative commitment are coupled in the epithelium of the small intestine. We developed a method for identifying cells in intact tissue containing DNA-bound MCM2-7. Interphase cells above the transit-amplifying compartment had no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Organoids
Share to Intestines
Share to Microvilli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to G1 Phase

Share to Intestinal Mucosa

Share to Staining and Labeling

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29599208
DOI: 10.1083/jcb.201708023
PMCID: PMC5940300

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.PMID 29599208Read ↗

Wnt/PCP-primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cellsSemantic proximity Read ↗

Mitotic errors drive rapid clearance of polyploidy during intestinal regeneration despite robust centrosome clusteringSemantic proximity Read ↗

SOX9-mediated G1 elongation confers reserve stem cell-associated injury resistance in human intestinal stem cellsSemantic proximity Read ↗

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.Semantic proximity Read ↗

Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregationSemantic proximity Read ↗

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomesSemantic proximity Read ↗

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.Semantic proximity Read ↗

Reduced Mcm2 Expression Results in Severe Stem/Progenitor Cell Deficiency and CancerSemantic proximity Read ↗

Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosisSemantic proximity Read ↗

Re-entry into mitosis and regeneration of intestinal stem cells through enteroblast dedifferentiation in <i>Drosophila</i> midgutsSemantic proximity Read ↗

Identification of Quiescent LGR5+ Stem Cells in the Human ColonSemantic proximity Read ↗

The stem cells of small intestinal crypts: where are they?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.