Article
Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non-Small Cell Lung Cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2018
Shibahara Daisuke, Tanaka Kentaro, Iwama Eiji, Kubo Naoki, Ota Keiichi, Azuma Koichi, Harada Taishi, Fujita Jiro, Nakanishi Yoichi, Okamoto Isamu
Abstract excerpt
INTRODUCTION: The interaction of programmed cell death ligand 2 (PD-L2) with programmed cell death 1 is implicated in tumor immune escape. The regulation of PD-L2 expression in tumor cells has remained unclear, however. We here examined intrinsic and extrinsic regulation of PD-L2 expression in NSCLC. METHODS: PD-L2 expression was evaluated by reverse transcription and real-time polymerase chain reaction analysis...
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