Article
Cytotoxic chemotherapeutic agents and the EGFR-TKI osimertinib induce calreticulin exposure in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 May 2021
Furukawa Rie, Inoue Hiroyuki, Yoneshima Yasuto, Tsutsumi Hirono, Iwama Eiji, Ikematsu Yuki, Ando Nobuhisa, Shiraishi Yoshimasa, Ota Keiichi, Tanaka Kentaro, Nakanishi Yoichi, Okamoto Isamu
Abstract excerpt
OBJECTIVES: Synergistic anticancer efficacy of combination treatment with immune checkpoint inhibitors (ICIs) and platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) may be attributable in part to the phenomenon of immunogenic cell death (ICD), which is characterized by the release of damage-associated molecular patterns (DAMPs) from dying tumor cells. The ability of cytotoxic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.