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Article

Induction of PD-L1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2015

Ota Keiichi, Azuma Koichi, Kawahara Akihiko, Hattori Satoshi, Iwama Eiji, Tanizaki Junko, Harada Taishi, Matsumoto Koichiro, Takayama Koichi, Takamori Shinzo, Kage Masayoshi, Hoshino Tomoaki, Nakanishi Yoichi, Okamoto Isamu

Abstract excerpt

PURPOSE: Therapies targeted to the immune checkpoint mediated by PD-1 and PD-L1 show antitumor activity in a subset of patients with non-small cell lung cancer (NSCLC). We have now examined PD-L1 expression and its regulation in NSCLC positive for the EML4-ALK fusion gene. EXPERIMENTAL DESIGN: Th...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 26019170
DOI: 10.1158/1078-0432.CCR-15-0016

Genes

ALK
EML4
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26019170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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