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Article

Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses

2 Sept 2009

Abstract excerpt

Muscle stem (satellite) cells are relatively resistant to cell-autonomous aging. Instead, their endogenous signaling profile and regenerative capacity is strongly influenced by the aged P-Smad3, differentiated niche, and by the aged circulation. With respect to muscle fibers, we previously established that a shift from active Notch to excessive transforming growth factor-beta (TGF-beta) induces CDK inhibitors in...

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PMID: 19732043
DOI: 10.1111/j.1474-9726.2009.00517.x

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