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Article

PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.

Nature cell biology - 1 Apr 2018

Yeh Hsi-Wen, Hsu En-Chi, Lee Szu-Shuo, Lang Yaw-Dong, Lin Yuh-Charn, Chang Chieh-Yu, Lee Suz-Yi, Gu De-Leung, Shih Jou-Ho, Ho Chun-Ming, Chen Chian-Feng, Chen Chiung-Tong, Tu Pang-Hsien, Cheng Ching-Feng, Chen Ruey-Hwa, Yang Ruey-Bing, Jou Yuh-Shan

Abstract excerpt

Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is needed to enable targeted intervention. Here, we show that paraspeckle component 1 (PSPC1), identified in an aberrant 13q12.11 locus, is upregulated and associated with poor survival in patients with cancer. PSPC1 promotes tumorigenesis, epithelial-to-mesenchymal transition...

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Source

Identifiers

PMID: 29593326
DOI: 10.1038/s41556-018-0062-y

Genes

PSPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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