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Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine Deaminase

21 May 2009

Abstract excerpt

The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A (A3A) has no effect on lentiviruses but dramatically inhibits replication of the parvovirus adeno-associated virus (AAV). To study the contribution of deaminase activity to the antiviral activity of A3A, we performed a comprehensive mutational...

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PMID: 19461882
DOI: 10.1371/journal.ppat.1000439

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Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine DeaminasePMID 19461882Read ↗

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